1427 matches in the database.
These are records: 1 - 30.
[1] [2] [3] [4] [5] … [48]
2.
Kabir, Fatema Q.
Phenomenon of Visual Perception Seen Over Wexner Center for Visual Arts and Knowlton School of Architecture.
Degree: Master of Architecture, Architecture, 2009, Ohio State University
► The visual world is about an individual's perception or understanding, while…
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▼ The visual world is about an individual's perception or understanding, while one unfolds the concepts of visual phenomenon multiple unknown characters come to fore. The realization of these changes is accredited to elapse of time and cognition of brain and eye. There are multiple layers involved in visual perception for knowing the intended phenomenon. In the first layer the characters are neutral and unidentified on the given picture plane. They create what is called the retinal images in the back of the eye. Once the brain registers these fragments in each other's proximity it is able to recognize the image as whole. The recognition may also be accredited to historicizing. The essence of visual perception lies in the analysis of the view; this could be in either of the following two ways; exploring the real from the created illusions or experiencing the overall space by getting integrated within, through the view. For a writer experiencing is the most important is well said by Maurice Merleau-Ponty; “How would the painter or poet express anything other than his encounter with the world?”1 For a writer of any field, experiencing what they write would be their practical knowledge. It plays the role of chemistry or biology laboratory. Similarly in architecture understanding human perceptions needs personal experiencing. Knowing that visual perception has multiple phenomenons to display, minimum number of structures studied could not be less than two and considering the factor of laboratory backup to my thesis (as I would call it), It was ideal for them to be located on Ohio State University campus. The cases studies carried out during the Thesis; explore the multiple layers of perception that happen in the structures. Peter Eisenman's Wexner Center of 1989 is probably one of his unintentional design that envelopes the optical illusion phenomenon of visual perception in it very artistically. The structure is one that functionalists might refute but experientialists would support. They would also support Mack Scogin Merill Elam Architects' Knowlton School of Architecture of 2004 which identifies Maurice Merleau-Ponty's phenomenology it its spatial quality. 1 - Pallasma, Juhani. The eyes of the skin: Architecture and the Senses, Touching the World. Great Britain, TJ international
Advisors/Committee Members: Mcmorrough, John.
Subjects: Architecture; Behaviorial sciences; Psychology
Keywords: visual perception, visual phenomenon, Optical illusion, Wexner Center, Knowlton School of Architecture, Phenomenology of Visual Perception
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3.
Kachi, Reiko.
Factors predicting native and nonnative listeners' evaluative reactions to Japanese English.
Degree: Doctor of Philosophy, Teaching and Learning, 2004, Ohio State University
► The World Englishes and English as an International Language (EIL) points of…
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▼ The World Englishes and English as an International Language (EIL) points of view have challenged the traditional schemes of applied linguistics research. Since English belongs to all the worldwide users, nonnative speakers’ perspectives should be acknowledged with as much attention as those of native speakers. Consequently, the current study investigated native and nonnative listeners’ evaluative reactions to and the intelligibility of Japanese English, a nonnative English variety. Japanese English was chosen as the target of investigation, due to the importance of English-medium international communication for Japanese people and its exemption from localized norms. Quantitative as well as qualitative methods were employed for triangulation and complementarity. In the ex post facto study, listeners’ native language backgrounds (i.e., American English, Hindi, Mandarin, and Japanese), as well as the speakers’ proficiency levels, were hypothesized as the predictors of the evaluative reactions to and the intelligibility of Japanese English. Also investigated as possible factors were the listeners’ gender, familiarity with Japanese English, and exposure to nonnative speakers of English other than Japanese English speakers. Eighty-four undergraduate and graduate students recruited at an American university listened to extemporaneous speech. The listeners evaluated it on a semantic differential scale and also completed a word-for-word dictation task for the intelligibility. For further qualitative interviews, thirteen participants were recruited from the ex post facto study. Regression analyses indicated that the Hindi speakers were the most critical of Japanese English while the American participants were the most positive about it, especially about rudimentary speakers. Reactions from Chinese and Japanese participants turned out to be similar. Japanese English speech was more intelligible than native speech, at least to Chinese and Japanese listeners. Interviews revealed that the Hindi speakers were irritated by the choppiness of Japanese speech, while the other nonnative participants were generally more sympathetic. The power imbalance among different types of English users was also articulated. Based on the results of the study, implications were presented for applied linguistics research and English education, especially where international communication was the goal of instruction. Additionally, recommendations for further studies were included.
Advisors/Committee Members: Samimy, Keiko K.
Keywords: English; World Englishes; English as an International Language; nonnative speakers; attitudes; evaluative reactions; intelligibility; Japanese English
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4.
Kachuba, John B.
The Reich Photographer's Tale.
Degree: Master of Arts (MA), English (Arts and Sciences), 2003, Ohio University
► The Reich Photographer’s Tale is a collection of six short stories, each…
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▼ The Reich Photographer’s Tale is a collection of six short stories, each of which is either true historical fiction, in which history itself serves as a character in that it has a direct affect upon other characters in the story, or historically-influenced fiction in which the history portrayed in the story is important, but secondary to, the motives of the characters. The distinction between these two forms of fiction is discussed at length in the Introduction. The genesis for the stories in this collection derive both from the author’s personal experiences as well as his strong interest in history and have been influenced by several who have written about historical events. A partial list of these writers includes John Barth, Thomas Berger, T.C. Boyle, Joseph Heller, William Styron, Kurt Vonnegut and James Welch.
Advisors/Committee Members: Spencer, Darrell.
Subjects: Literature, English
Keywords: Short Stories; English Literature; Thesis; historical fiction
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5.
Kacsir, Marci Adair.
If I Had a Puppy.
Degree: Master of Arts, Creative Writing, 2006, Miami University
► This manuscript is focused on poetry that combines the musicality of language…
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▼ This manuscript is focused on poetry that combines the musicality of language with a limited space specifically so that the attention to language is heightened. I hope to get the readers involved in the poems through this kind of hyper-awareness and, at times, direct address. Directly speaking to my audience allows me to involve the readers in contemporary conversations in a way that less direct approaches often do not. Also, smaller, compressed forms offer a dimension of pressure on the line, call attention to the music in the language, and lend themselves to social commentary in a way I find particularly interesting. These poems are also influenced by the lyric tradition, especially the colloquial quality in the ballads. I see brevity not as a challenge but as an opportunity to leave something lingering with the audience long after the poem as been read.
Advisors/Committee Members: Tuma, Keith.
Subjects: Fine Arts
Keywords: direct address; compressed forms; colloquial; social commentary; musicality of language
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6.
Kaczorowski, Kimberly E.
The Anatomy of Love: What It Is, With All the Kinds, Causes, Symptoms, Prognostics, and Several Cures of It.
Degree: Master of Arts, Creative Writing, 2009, Miami University
► This is a collection of short stories that take place in, or…
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▼ This is a collection of short stories that take place in, or are influenced by events that originated at, Athens, Georgia. Several members in a group of friends fall in and out of love and mature over a period of eight years. Through the length of the manuscript with the use of animal images and long descriptions of houses and landscape I aim to alter the way characters are formed in fiction.
Advisors/Committee Members: Goodman, Eric.
Subjects: American literature; English literature; Fine Arts
Keywords: creative writing; short stories; interlinked short stories; southern literature; love stories; animal stories
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7.
KADAMBARI, SIREESHA.
USING TRACKING AND BUFFERING TO IMPROVE DELIVERY PERFORMANCE IN AD HOC NETWORKS.
Degree: MS, Engineering : Computer Engineering, 2003, University of Cincinnati
► An ad hoc network is a collection of wireless mobile hosts dynamically…
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▼ An ad hoc network is a collection of wireless mobile hosts dynamically forming a network without the use of any existing stationary network infrastructure. If two nodes in an ad hoc network are not in each other's communication range, data packets must be routed by intermediate nodes. Routing in an ad hoc networks is a significant challenge because of the difficulty in maintaining a successful communication path between a source-destination pair in spite of changing topology. This is complicated by the fact that most wireless networks have low bandwidth, thus routing and data forwarding must be done prudently so as not to overwhelm a low capacity network. A significant amount of work has been done in designing efficient routing protocols for mobile ad hoc networks and many routing protocols have been developed. The focus of the community, however, has been on best effort traffic where packets must be routed as quickly as possible with minimum possible delay. However, it turns out that routing performance in terms of bandwidth usage and throughput may improve if packets are allowed to wait in buffers at the source or at intermediate nodes and are delivered to destinations with a minimum number of hop-wise transmissions at opportune moments. This obviously reduces bandwidth usage as a small number of transmissions are needed to deliver a packet. It also indirectly improves throughput as packet losses become less likely as packets are buffered when routes are unavailable and also packets are exposed less to wireless channel errors. However, the buffering increases end-to-end packet delay; so such an approach is applicable only to delay-tolerant applications. Also, care must be taken to prevent starvation where packets wait indefinitely in the buffers. In this thesis, we design and develop two location-based routing protocols "Geographic Forwarding with Buffering" and "Topology Based Forwarding with Buffering" based on the above idea that encourages buffering to gain better bandwidth usage and lower packet loss. The protocols use intelligent location tracking. Tracking is provided by a dead reckoning-based location service developed earlier. Packets are buffered when the destination is far and forwarded when it comes near. Packets are also buffered when congestion develops or when no route is available. The protocols are implemented in the network simulator Glomosim and their performance is evaluated against two standard routing protocols: one location based - GPSR and the other non-location based - AODV. The evaluations show that our protocols offer much better packet delivery ratios, often close to 100 % as well as a significant reduction in average hop-wise transmissions per packet, while the end-to-end delay degrades only slightly.
Advisors/Committee Members: Das, Dr. Samir R.
Keywords: Ad Hoc Networks; routing protocols; wireless networks; bandwidth; location tracking
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8.
KADAM, PRASAD H.
DEVELOPMENT AND COMPARISON OF ANALYTIC, NUMERICAL AND EXPERIMENTAL TECHNIQUES TO FORMULATE FOUR-POLE MATRICES OF THREE-DIMENSIONAL ACOUSTIC SYSTEMS.
Degree: MS, Engineering : Mechanical Engineering, 2006, University of Cincinnati
► Four-pole matrix approach is a very convenient concept in modeling acoustic systems,…
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▼ Four-pole matrix approach is a very convenient concept in modeling acoustic systems, its application has been limited mainly to systems composed of only one-dimensional (1-D) or lumped parameter elements due to the difficulty in formulating four poles of three dimensional (3-D) cavities. In this work, an experimental procedure is developed to obtain four poles of 3-D cavities. The procedure is validated by comparing the four poles obtained experimentally for a rigid-walled rectangular cavity with the four poles obtained by analytical and numerical procedures. Establishing an experimental procedure for four pole formulation is significant as it enables application of the four pole approach to virtually any acoustic systems. The concept of hybrid modeling, which is building the system model by combining experimental, numerical and analytical models, is demonstrated through a simple example as the best application of the four pole approach.
Advisors/Committee Members: Kim, Dr. Jay H.
Subjects: Engineering, Mechanical
Keywords: Acoustics, Hybrid Modeling, Four Pole Matrix, Data Acquisition
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9.
Kadiyala, Akhil.
Identification of Factors Affecting Contaminant Levels and Determination of Infiltration of Ambient Contaminants in Public Transport Buses Operating on Biodiesel and ULSD Fuels.
Degree: Master of Science in Civil Engineering, Civil Engineering, 2008, University of Toledo
► This experimental project presents a comprehensive study of indoor pollutant behavior in…
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▼ This experimental project presents a comprehensive study of indoor pollutant behavior in the public transport buses in the city of Toledo running on alternative fuels and an understanding of the contribution of outdoor pollutant concentrations to in-vehicle pollutant levels. The indoor pollutants monitored are particulate matter, carbon dioxide, carbon monoxide, sulphur dioxide, nitric oxide, and nitrogen dioxide. Temperature and relative humidity are also measured inside the vehicle in addition to the in-vehicle pollutants. The various factors affecting indoor air quality are indoor sources of pollutants (people, furniture, etc.), ventilation, outdoor air quality, meteorology, pollutant decay, and vehicular traffic. The diurnal, monthly, and seasonal variations of the pollutants are studied. The pollutant level buildup within a bus compartment is due to a combination of different factors and not a result of variation due to a single variable. As the bus is in motion and factors influencing the indoor pollutant levels keep changing randomly, it is difficult to identify specific monthly and seasonal trends. However, pollutant concentration levels are found to be highly influenced by peak hours in the morning and evening and a discussion is provided on identifying the factors that could have influenced monthly and seasonal variations. Relatively higher pollutant concentrations are observed for majority of the pollutants in winter when there is not much air exchange in the bus compartment. The trend study revealed that the concentrations were mainly influenced by peak hours, ventilation settings, vehicular traffic, passenger ridership, and meteorology. The factors influencing pollutant levels with respect to month and season are identified. The regression tree analysis helped identify the various factors affecting in-vehicle pollutant levels and the relationships between independent variables and indoor pollutant concentrations. The meteorological effect study revealed wind direction to be the most significant meteorological variable for all the gaseous pollutants while particulate matter levels are found to be mainly influenced by ambient PM2.5 concentrations and visibility. Different combinations of variables were able to explain the trends of monitored indoor pollutants. The contribution of ambient concentration to the indoor concentration levels was determined by calculating infiltration factors using two different methods for both biodiesel and ULSD buses. The analysis revealed that the indoor air quality levels are better in a biodiesel bus as compared to the ULSD bus. It was also observed that nearly 50-70% of the pollutants found indoors are generated outdoors for all the pollutants except nitrogen dioxide. Exposure of passengers and drivers to the indoor pollutants monitored were determined using time weighted concentration and compared to available health standards. The study revealed that the drivers are safe from exposure to gaseous as well as particulate contaminants. It is hoped that this study and analysis of in-vehicle pollutant trends will provide crucial information to indoor air quality regulators and decision makers in understanding the IAQ in transit vehicles and to regulate the indoor air quality standards.
Advisors/Committee Members: Kumar, Ashok.
Subjects: Civil engineering; Environmental engineering; Transportation
Keywords: Indoor Air Quality, Regression Tree Analysis, CART, Infiltration factor, Alternative fuels, Biodiesel, ULSD, Public Transport, TARTA, Exposure
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10.
KADLECK, COLLEEN.
POLICE UNIONS: AN EMPIRICAL EXAMINATION.
Degree: PhD, Education : Criminal Justice, 2001, University of Cincinnati
► Police employee organizations and unions have long been seen as obstacles to…
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▼ Police employee organizations and unions have long been seen as obstacles to police chiefs and to policy implementation (Walker 1984). More recently, police unions have been identified as an obstacle to the implementation of community policing (Sadd and Grinc 1996). While much has been written concerning police unions, most of the studies are based on anecdotal accounts of police labor relations in a particular department (see Levi 1977 for a representative piece of union research). Police unions have yet to be described or examined empirically. This work uses a large representative sample of police agencies as a starting point to survey both police chiefs and police union leaders to answer three major research questions: (1) what are the characteristics of the typical police employee organization? (2) what are police chief and police employee organization leader perceptions of police labor relationships? and (3) to what extent do police employee organizations interfere with the implementation of community policing? The findings of this research suggest that police employee organizations share many of the characteristics of police agencies: most are relatively small and locally based. Police chiefs and police employee organization leaders have somewhat different perceptions of police labor relationships and these perceptions appear to be related to experience and conflict. Very few police chiefs or police employee organization leaders reported conflict over the implementation of community policing in the last three years.
Advisors/Committee Members: Travis, III, Dr. Lawrence F.
Subjects: Sociology, Criminology and Penology
Keywords: POLICE UNIONS; LABOR RELATIONS; COMMUNITY POLICING; HISTORY OF POLICE UNIONS
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11.
Kadowaki, Tatsuhiko.
Nucleocytoplasmic transport ofmRNA in Saccharomyces cerevisiae.
Degree: Doctor of Philosophy, Pathology, 1994, Case Western Reserve University
► Nucleocytoplasmic transport of macromolecules across nuclear membrane was the essential invention during…
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▼ Nucleocytoplasmic transport of macromolecules across nuclear membrane was the essential invention during evolution of eukaryotes. This bidirectional transport is carried out by a machine, the nuclear pore complex, that is anchored in both layers of the nuclear envelope. Although significant progress has been made in understanding of the mechanisms of nuclear protein import, very little is known about the mechanisms of RNA export from nucleus to cytoplasm. To learn molecular and cellular mechanisms of mRNA transport, a genetic approach using Saccharomyces cerevisiae, i.e., the isolation of mRNA transport defective (mtr) mutants followed by their characterization was undertaken. Twenty one temperature sensitive mutants that accumulate polyA+RNA in the nucleus at the restrictive temperature were isolated by a suicide selection enrichment procedure and by a screen of random temperature sensitive mutants. These mtr mutants were classified into sixteen different complementation groups, mtr1-mtr16. The mutants also exhibit different accumulation patterns of polyA+RNA in the nucleus, suggesting they might have lesions in the different steps of mRNA transport pathway. The first of mtr mutants, mtr1-1 has been characterized in detail and it has multiple defects on RNA processing and transport. Since the structure of mRNA synthesized in mtr1-1 is substantially normal, the mtr1-1 mutation affects the mRNA transport machinery. MTR1 and its homologs are nuclear proteins consisting of seven repeat units and appear to encode guanine nucleotide release proteins on small nuclear GTPases. It is therefore proposed MTR1 and its homologs act as regulators for RNA processing and transport by activating nuclear GTPases. This function is universal in various species and not related to the regulation of cell cycle progression or the state of chromatin organization. The second mtr mutant, mtr2-1 has been characterized, and mRNA export is blocked at the intermediate path of mRNA export in this mutant. PolyA+RNA accumulated in the nucleus closely associates with nucleolar proteins, suggesting the possible interaction between the nucleolus and the mRNA transport machinery. MTR2 is a 21kD protein which is poorly expressed and concentrated in the nucleus.
Advisors/Committee Members: Tartakoff, Alan M.
Keywords: Nucleocytoplasmic transport of mRNA Saccharomyces cerevisiae
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12.
Kaelber, Kara Young.
Empathy and Self-Construals: An Exploratory Study of Eastern and Western Master's-Level Counseling Students.
Degree: Doctor of Philosophy, Counselor Education and Supervision, 2008, University of Akron
► The purpose of this study was to explore the degree of empathy…
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▼ The purpose of this study was to explore the degree of empathy between Eastern and Western master…#8482;s-level counseling students and the relationship between the degree of empathy and the level of self-construals among those students. Participants consisted of 101 students enrolled in counseling programs at two universities, one in Thailand (n = 48) and the other in the Midwestern United States of America (n = 53). The participants were administered the Interpersonal Reactivity Index (IRI; Davis, 1980), used to measure three types of empathy, and the Self-Construal Scale (SCS; Singelis, 1994), used to measure independent and interdependent self-construals. A multivariate analysis of variance (MANOVA) revealed that the Western group of participants displayed significantly higher IRI scores on the subscales of Perspective Taking and Empathic Concern than did the Eastern group of participants. Bivariate correlational analyses indicated a significant, positive relationship between the SCS independent scores and the IRI scores on the subscales of Perspective Taking, Empathic Concern, and Fantasy Scale. However, it should be noted that these results cannot be inferred to mean that Western master…#8482;s-level counseling students are more empathic than Eastern master…#8482;s-level counseling students, or that an independent self-construal leads to increased empathy. Although prior cross-cultural research demonstrated that Western and Eastern persons have different linguistic, cognitive, and affective expressions, follow-up statistical analyses demonstrated that Western and Eastern participants did not significantly differ in SCS scores (i.e., independent versus interdependent self-construals), which suggested that the sample population was more homogeneous in their cultural orientations than anticipated. Finally, factors unrelated to this study…#8482;s research design,such as the degree of training of empathy, may have influenced the results in spurious ways. Because the results showed that Western participants evidenced a greater number of semesters in their master…#8482;s-level counseling program than Eastern participants, and the number of semesters of study was significantly positively correlated with IRI scores, perhaps, master…#8482;s-level training influenced results over and above participants…#8482; cultural orientation. The implications of these findings for counselor education, supervision, practice and research and recommendations for future cross-cultural empathy research were discussed.
Advisors/Committee Members: Schwartz, Robert.
Subjects: Academic guidance counseling; Adult education; American studies; Asian literature; Behaviorial sciences; Education; Multicultural education; Personal relationships; Psychology; Social psychology; Social research; Social structure
Keywords: empathy; self-construals; independent self-construals; interdependent self-construals; independence; interdependence; cross-cultural empathy; Western; Eastern; master's-level counseling students; individualism; collectivism; The United States of America
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13.
Kaercher, Julianne C.
Female Duality and Petrarchan Ideals in Titian's Sacred And Profane Love.
Degree: Master of Arts (MA), Art/Art History, 2009, Bowling Green State University
► Painted around 1514 in Venice, Titian's Sacred and Profane Love has long…
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▼ Painted around 1514 in Venice, Titian's Sacred and Profane Love has long been the subject of debate in Art History. Building on previous scholarship, including work from Charles Hope, Walter Friedläender, and Rona Goffen, this essay looks into the triangulated relationship created between the two women and the viewer through real and implied gazes, and how this relationship addresses a specific patron's desire to self-fashion an identity that would be projected for a specific audience. Where previous scholars have argued that Niccolò Aurelio commissioned this painting as a wedding gift, this paper suggests a new reading of the commissioning in light of the female patron, Laura Bagarotto, and her desire to self-fashion an identity not only to her new husband, but also to the society in which she newly found herself a part. In addition to the discussion on patronage, this paper will use Petrarch's writings and influence as a frame for the examination of Titian's Sacred and Profane Love by exploring Petrarchan conceptions of the ideal woman and connecting the double figuration in the painting to Laura Bagarotto's dual roles as bride and widow. In so doing, this essay provides a new interpretation of the idealized renaissance female by drawing attention to the inherent duality of women, identified by Petrarch, as conflicting yet necessary female characteristics. Approaching this painting multi-dimensionally” looking at the influence of Petrarch, the social circumstances surrounding the commissioning, and examining other artistic representations of idealized women” it will be possible to question the assumed male patronage of the piece.
Advisors/Committee Members: Terry, Allie.
Subjects: Art History
Keywords: Titian; Sacred and Profane Love; Petrarch; patronage
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14.
Kaewsakhorn, Thattawan.
Roles of calcitriol and its analog on canine transitional cell carcinoma in vitro and in vivo, and in normal canine prostate tissue explaints.
Degree: Doctor of Philosophy, Veterinary Biosciences, 2007, Ohio State University
► Although increasing data indicates inhibitory roles of calcitriol on tumor growth in…
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▼ Although increasing data indicates inhibitory roles of calcitriol on tumor growth in humans, little is known about its effects on canine tumors. The objectives of this study are to investigate the effects of calcitriol and its analogs on canine transitional cell carcinoma and canine prostate tissue explants. First, we investigated effects of calcitriol, seocalcitol and medium-chain triglyceride (MCT) on a canine transitional cell carcinoma cell line (TCC). The effects of calcitriol and seocalcitol on cell growth, cell cycle, vitamin D receptor (VDR) and Bcl-2 expression were determined with/without MCT. Second, we established a canine TCC mouse-xenograft model and used this model to examine effects of calcitriol, seocalcitol, and piroxicam on tumor growth. Third, the effects of calcitriol and dihydrotestosterone (DHT) were evaluated on arginine esterase (AE) acitivity and VDR expression in normal canine prostate tissue explants. In summary, our results showed that the VDR is present in canine TCC tumor and in the canine prostate. Calcitriol and seocalcitol significantly inhibited cell growth and calcitriol caused cell cycle arrest. Bcl-2 expression was decreased in cells treated with these compounds, although no significant changes in VDR expression were observed. MCT enhanced the growth-inhibitory effects of both compounds. We developed and used a canine TCC-mouse xenograft model to evaluate and compare the inhibitory effects of calcitriol, seocalcitol and piroxicam. Results showed that only seocalcitol reduced tumor volume compared to controls. The inhibitory effect of seocalcitol on tumor growth was supported by data from a Ki-67 staining. Blood calcium was higher in both calcitriol-and seocalcitol-treated mice compared to controls. In summary, our findings suggest a potential use for calcitriol and seocalcitol for the treatment canine TCC. We demonstrated that DHT increased AE activity and VDR expression in canine prostate tissue explants; however, there was no increase in AE activity in calcitriol-treated explants and a decreased in VDR expression. These results indicated that canine prostate tissue explants are a valuable model for the study of prostate pathobiology and pharmaceutical interventions. They also provided a basis for further investigation of roles of calcitriol as a therapeutic/preventative agent in benign prostatic hyperplasia in both dogs and humans.
Advisors/Committee Members: Inpanbutr, Nongnuch.
Keywords: calcitriol, seocalcitol, canine transitional cell carcinoma, canine prostate gland
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15.
Kaewsuya, Pakritsadang.
Fluorescent Determination of Cardiolipin using 10-N-nonyl Acridine Orange.
Degree: Master of Science, Chemistry, 2007, Miami University
► Cardiolipin (CL) plays an essential role as a marker for cell apoptosis.…
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▼ Cardiolipin (CL) plays an essential role as a marker for cell apoptosis. Quantitative detection of phospholipids (PLs) by UV absorbance is problematic due to the presence of only isolated double bonds in the structure. Although 10-N-nonyl acridine orange (NAO) has been utilized for fluorescent detection of liposomes and mitochondria through its interaction with CL, specific quantitative determination of CL in solution using NAO is uncommon. In this work, we have developed a fluorescence quenching method for CL using NAO. The optimum excitations are 499 and 518 nm at low and high NAO concentration, respectively. The optimum emissions are varied from 518 to 530 nm. The interaction of sodium n-dodecyl sulfate (SDS), sometimes used for lipid extraction from cells, and other PLs such as phosphatidic acid (PA), phosphatidylcholine (PC), phosphatidylethnolamine (PE), phosphatidylglycerol (PG), phosphatdiylserine (PS), sphingomyelin (SM) and cholesterol, with NAO is investigated. The fluorescence intensity of 0.5 µM NAO signal is strongly quenched by SDS below 25% methanol in water. With a methanol content above 50%, no quenching of NAO by SDS or the PLs with the exception of PG above 8 µM is observed. Using 50-50 methanol-water, the fluorescence as a function of reaction time for the NAO-CL interaction is quite stable from 3 to at least 15 min. Concentrations of 5, 10, 20, and 50 µM NAO are considered and 20 µM NAO provides a linear fluorescence response from 0.2 – 10 µM CL. The detection limit is 0.2 µM and the limit of quantification is 0.6 µM. Acridine orange (AO) and phenosafranin (PSF) dyes are less effective as fluorescent probes for CL. CL in whole cell and membrane samples is quantitatively determined by standard addition to be in the 0.2-1.5 µM range. The increase of CL as compared to the controls is not significantly different in all samples subjected to cell death using staurosporine.
Advisors/Committee Members: Danielson, Neil D.
Subjects: Chemistry, Analytical
Keywords: Fluorescence; Cardiolipin; Phospholipids; 10-Nonyl acridine orange
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16.
Kaffashi, Farhad.
VARIABILITY ANALYSIS and ITS APPLICATIONS TO PHYSIOLOGICAL TIME SERIES DATA.
Degree: Doctor of Philosophy, Electrical Engineering, 2007, Case Western Reserve University
► In this thesis, novel variability analysis techniques are developed and refinements are…
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▼ In this thesis, novel variability analysis techniques are developed and refinements are made to some currently available methods to enhance their use and effectiveness. These variability analysis techniques are applied to physiological time series data to study both health and disease. In particular, the addition of a new parameter, the time delay, is proposed to enhance the performance of Approximate and Sample Entropy calculations; a novel technique is developed to estimate the gradient of power law behavior based on non-parametric change-point detection; a novel technique is developed to quantify the coupling between time series data based on surrogate data analysis, and the limitations of Detrended Fluctuation Analysis (DFA) are studied in the context of the detection of self similarities in EEG time series data. The techniques that are developed in the thesis are applied in several areas to evaluate their suitability and ffectiveness. In one application, neurodevelopment and maturation of the neonatal brain is studied and the effectiveness of strategies that can improve sleep organization, such as skin-to-skin contact or Kangaroo Care (KC) intervention, are evaluated using Approximate and Sample Entropy. The results show that the KC intervention improves neurodevelopment and maturation. In a study of epilepsy, a novel technique to quantify electrocorticography data using the DFA is presented. The DFA can detect changes in the electrical activity of the brain that are associated with different brain states such as seizure (ictal), preictal, postictal as well as arousals that are occurring during sleep. In the analysis of respiratory data, the complexity of in vitro modularly prepared neonatal rat slices, that are capable of generating a spontaneous respiratory related rhythm at different extra cellular K+ levels are quantified and further, the coupling between the respiratory and cardiac networks is investigated using a novel approach based on surrogate data analysis.
Advisors/Committee Members: Loparo, Kenneth A.
Subjects: Engineering, Biomedical
Keywords: Epilepsy; Neonatal EEG; Respiration; Variability Analysis; Approximate Entropy; Sample Entropy
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18.
Kagdi, Huzefa H.
Mining Software Repositories to Support Software Evolution.
Degree: PHD, College of Arts and Sciences / Department of Computer Science, 2008, Kent State University
► The dissertation presents an approach that uncovers evolutionary couplings from the version…
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▼ The dissertation presents an approach that uncovers evolutionary couplings from the version histories of software systems. The version histories used are those stored in software repositories, managed by version-control tools such as Subversion and CVS. A combination of lightweight source-code analysis and differencing, development heuristics, and sequential-pattern mining techniques are used to uncover the evolutionary couplings. Evolutionary couplings are identified between different artifact types (e.g., source code and documentation and end-user documentation in different natural languages), as well as at fine-grained granularities (e.g., methods, control statements, preprocessor, and even comments) of source code. The specific archival source used is the commits stored in software repositories. This work directly falls under the realm of Mining Software Repositories (MSR) and Empirical Software Engineering. The applications of evolutionary couplings are demonstrated on a number of software evolution tasks such as change analysis and prediction, software traceability links recovery, and software document localization process. The approach is applied and evaluated on a number of versions of K Desktop Environment (KDE) - an open source system. The results show that the approach is very precise in predicting certain types of future changes from the past evolutionary couplings. No other work has systematically shown the use of version archives in uncovering traceability links, supporting document localization, and source code change prediction at fine-granularity levels over multiple versions. Additionally, the approach is used to automatically mine latent programming rules, consisting of function calls and their syntactic context, and their violations (e.g., a missing or out of order call) from a large body of source code. The inclusion of call order and syntactic context is a substantial step forward from previous work. Version histories of open source systems Linux Kernel and Apache httpd server are used in the evaluation process. The results show that the approach is able to uncover rules and violations that a previous approach did not. Finally, an in-depth survey and the first taxonomy of MSR approaches also resulted from this work as a byproduct.
Advisors/Committee Members: Maletic, Jonathan.
Subjects: Computer science
Keywords: Software Engineering, Software Evolution, Mining Software Repositories, MSR, Source Code Analysis, Software Traceability, Change Analysis and Managment
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19.
Kahane, Alexandra L.
Restriction of DNA conformation by spirocyclic annulation at C4': synthesis of the nucleoside building blocks.
Degree: Doctor of Philosophy, Chemistry, 2004, Ohio State University
► The development of novel oligonucleotide analogues displaying well defined and predictable association…
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▼ The development of novel oligonucleotide analogues displaying well defined and predictable association patterns with high complex stabilities are of considerable current interest as antisense therapeutics. We have designed a new class of conformationally restricted nucleoside analogues based on modification of the glycosyl moiety by spirocyclic annulation at C4’. This modification is hypothesized to impart resistance to cellular nucleases, provide enhanced duplex stability due to the resultant structural preorganization, and bestow increased lipophilicity relative to natural nucleosides. The sum of these adjustments should result, upon oligomerization, in the formation of ideal candidates for antisense therapies. In addition, these analogues may possess potent antiviral activities. A divergent strategy has been implemented to provide access to analogues based on each of the 2-deoxyribose, 2,3-dideoxyribose, 2,3-didehydro-2,3-dideoxyribose and ribose frameworks from a common lactone intermediate. This lactone is accessible in enantiopure form via an oxonium induced pinacolic ring expansion reaction, subsequent optical resolution through the use of R-(-)-mandelic acid, and simple functional group interconversion. Elaboration of the lactone to the 2-deoxyribose and ribose frameworks was achieved via a butenolide intermediate. Vorbruggen type glycosylation provided the spirocyclic 2’-deoxyribonucleoside analogues in good selectivities (88-100%) and moderate chemical yields (45-59%). However, application of this strategy to the spirocyclic ribonucleosides was not feasible. Introduction of an alpha-phenylthio substituent to the lactone allowed the stereoselective introduction of the nucleic bases. Oxidative elimination of the sulfide provided entry into the spirocyclic 2’,3’-dideoxy-, 2’,3’-didehydro-2’,3’-dideoxy-and ribonucleoside analogues. Access to spirocyclic 2’,3’-dideoxyribonucleoside analogues containing adenine was achieved by the application of sodium salt glycosylation methodology to the lactone intermediate. The array of conformationally restricted nucleosides produced includes representatives resembling each of the 2-deoxyribose, 2,3-dideoxyribose, 2,3-dideoxy-2,3-didehydroribose and ribose frameworks. Although a variety of glycosylation methods were needed, each analogue was isolated as a pure, beta diastereomer. With a viable synthetic route developed, these analogues were made available for antiviral evaluation and future incorporation into oligomers for assessment as antisense therapeutics. Indeed, uridine 4-10a has already been shown to be an inhibitor of human corona virus.
Advisors/Committee Members: Paquette, Leo A.
Subjects: Chemistry, Organic
Keywords: Nucleoside Analogue
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20.
Kahil, Souhad.
A Rhetorical Examination and Critique of Hezbollah, the Party of God.
Degree: Doctor of Philosophy (Ph.D.), Communication Studies, 2006, Bowling Green State University
► Rhetorical examination and critique of Hezbollah – the Party of God is an…
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▼ Rhetorical examination and critique of Hezbollah – the Party of God is an analysis and interpretation, of Hezbollah as a social movement whose discourse is rooted in Arabic and Islamic discourse traditions. Hezbollah is a poorly understood movement. It is portrayed as a one-dimensional terrorist group. Hezbollah members are portrayed as plane hijackers, kidnappers and suicide bombers. But the Party of God has a rhetorical life – even the rhetorical construction of the martyr is worth examination from a culturalperspective. The following study examines how persuasive discourse constructs Hezbollah identity and purpose. Further, this study examines how the political and military elements in the context of Lebanese modernism are reflected in movement’s discourse.
Advisors/Committee Members: Gonzalez, Alberto.
Subjects: Speech Communication
Keywords: Hezbollah; Cultural Rhetoric; Social Movements; Middle East; Islamic Resistance
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21.
Kahle, Diane Kay.
HOW ELEMENTARY SCHOOL TEACHERS MATHEMATICAL SELF-EFFICACY AND MATHEMATICS TEACHING SELF-EFFICACY RELATE TO CONCEPTUALLY AND PROCEDURALLY ORIENTED TEACHING PRACTICES.
Degree: Doctor of Philosophy, Educational Theory and Practice, 2008, Ohio State University
► The purpose of this mixed method study was to explore the relationships…
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▼ The purpose of this mixed method study was to explore the relationships among the variables of mathematics self-efficacy, mathematics teaching self-efficacy, and procedurally or conceptually-oriented teaching methods. The study included 75 practicing elementary teachers who teach mathematics as well as other subjects. These teachers completed the Mathematics Teaching and Mathematics Self-Efficacy survey, designed as part of the study and based on the Mathematics Self-Efficacy Scale - Revised (MSES-R) and the Mathematics Teaching Efficacy Beliefs Instrument (MTEBI). Sixteen of the teachers also participated in an interview probing teaching methods for two mathematics topics the teachers believed they are most confident or least confident teaching. Interviews were assessed using the Conceptually and Procedurally Oriented Teaching Method Frequency Chart, designed as part of the study. Quantitative data analysis methods include descriptive statistics, Pearsons Product Moment correlation, and chi-square tests. Qualitative data analysis includes case study anecdotes for two of the interviewed teachers. Results indicate a strong relationship between mathematics self-efficacy and mathematics teaching self-efficacy and suggest that mathematics self-efficacy may be a precursor to mathematics teaching self-efficacy. Additionally, results indicate that when teaching their most confident mathematics topic teachers are more likely to use conceptually oriented teaching methods and when teaching their least confident mathematics topic teachers are more likely to use procedurally oriented teaching methods. This study offers findings to mathematics teacher educators and elementary mathematics teachers about the importance of developing mathematics self-efficacy and mathematics teaching self-efficacy because of their relationship to teachers choices of instructional methods. Additionally the two instruments developed in the study will help future researchers assess these variables.
Advisors/Committee Members: Wagner, Sigrid.
Subjects: Mathematics education
Keywords: Mathematics, Education, Teaching, Self-Efficacy, Procedural and Conceptual Understanding
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22.
Kahlenberg, Joanne Michelle.
Activation of Caspase-1 Signaling Complexes by the P2X7 Receptor Requires Intracellular K + Efflux and Protein Synthesis Induced by Priming with Toll-Like Receptor Ligands.
Degree: Doctor of Philosophy, Pathology, 2004, Case Western Reserve University
► Recent advances in understanding of the biology underlying hereditary inflammatory diseases have…
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▼ Recent advances in understanding of the biology underlying hereditary inflammatory diseases have focused attention on the importance of regulating levels of the proinflammatory cytokine IL-1beta to prevent systematic inflammation. Diseases such as Muckle-Wells Syndrome and Familial Mediterranean Fever are characterized by inflammatory arthritis, episodic fevers and rashes, and amyloid deposition as well as elevated serum levels of IL-1beta. These inflammatory symptoms can be eliminated by antagonists to the IL-1beta receptor, stressing the role of elevated IL-1beta levels in inducing these inflammatory phenotypes. Additionally, the identification of genetic mutations underlying these inflammatory diseases has aided in the identification of a complex of molecules, termed the inflammasome, which recruits and activates caspase-1, the enzyme responsible for the cleavage of IL-1beta to its active form. The mechanisms regulating formation of the inflammasome remain ill defined but critical for the treatment and prevention of these and other inflammatory diseases. In this thesis, the mechanisms of caspase-1 activation between human monocyte (THP-1) and murine macrophage (Bac1) model systems are explored and defined. In particular, the assembly of caspase-1 activating complexes by a well-characterized activator of caspase-1, the P2X7 Receptor (P2X7R), is addressed. We show that intracellular K + efflux following P2X7R activation is important for the induction of stable caspase-1 activating complexes, such as the inflammasome. This induction most likely requires the activity of Ca ++ -independent phospholipase A2. Additionally, we demonstrate that Toll-Like Receptor (TLR) activation of NFkappaB-mediated transcription is essential for the P2X7R to activate caspase-1, suggesting that essential components of the inflammasome are not present in Bac1 macrophages at basal levels. Thus, we demonstrate that in order to rapidly assemble the inflammasome, cells must be treated with TLR agonists before activation of the P2X7R or treatment with other K + release stimuli. These findings are among the first to show that activation of the P2X7R results in inflammasome assembly and caspase-1 activation, and they suggest that there is an important link between the P2X7R and innate immune signaling mechanisms.
Advisors/Committee Members: Dubyak, George R.
Keywords: Caspase-1; IL-1beta; Inflammasome; Macrophage; Monocyte; Potassium; Toll-Like Receptors
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23.
Kahle, Nicole L.
The Effects of Core Stability Training on Balance Testing in Young, Healthy Adults.
Degree: B.S. in Exercise Science, Exercise Science, 2009, University of Toledo Honors Theses
► Dynamic balance is a key component of normal daily activities such as…
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▼ Dynamic balance is a key component of normal daily activities such as walking, running and climbing stairs. Since balance is such an important aspect of every day life, it is imperative to find programs useful for maintaining proper balance. One such suggestion that has been made in an effort to improve balance is the correlation between muscular strength training and enhanced balance. Training the core muscles especially has been hypothesized as an improvement program, but there is a lack of current scientific evidence to support this claim. Further investigation on the effect of a core stability program on balance is therefore needed in a effort to provide a balance maintenance program. Therefore, this study sets out to compare the effects of a core stability program on dynamic balance as measured with the Star Excursion Balance Test. Thirty participants (15 male, 15 female) with no known musculoskeletal injuries or neurologic deficits volunteered for the study. The participants were randomly divided into two groups, a control group and an exercise group. The control group performed an initial Star Excursion Balance Test followed by six weeks of no core strengthening exercises and a second Star Excursion Balance Test. The exercise group performed the first Star Excursion Balance Test followed by six weeks of a core stability program and a second Star Excursion test. The maximum excursion distances as normalized to leg length were recorded for each test. For a majority of the reach directions, maximum excursion distances improved for the exercise group when compared to the control group. This improvement in reach distance justifies the proposal of core strengthening improving dynamic postural control.
Advisors/Committee Members: Gribble, Phillip.
Subjects: Sports medicine
Keywords: Core Stability, Dynamic Balance, Star Excursion Balance Test
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24.
Kahn, Meghan Cornelia.
Goal Location Memory in Pigeons: Roles of the Hippocampal Formation and Visual Wulst.
Degree: Doctor of Philosophy (Ph.D.), Psychology/Experimental, 2009, Bowling Green State University
► The abilities of homing pigeons (Columba livia) to navigate through unfamiliar territory…
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▼ The abilities of homing pigeons (Columba livia) to navigate through unfamiliar territory and locate goals using visual cues have been well described. Recent recordings from single cells in the pigeon hippocampal formation (HF) also suggested that pigeons represent what happens at particular locations, that the HF is recruited in such representations, and that the right and left sides of HF participate differently in such representations. The present study examined if the hippocampal formation and a connected visual learning area, the Wulst, of homing pigeons were necessary for learning the contents of different goal locations in an open-field, laboratory environment. Results showed that while control animals were able to distinguish between two different goal locations, pigeons with bilateral hippocampal lesions were impaired at goal discrimination, even though feature cues could have been used to distinguish between goal locations. Unilateral HF lesions revealed that the right HF was more important for content learning than left HF. Wulst lesion pigeons also showed impaired content learning during training, but not testing. Of interest, probe data indicated that left HF and the Wulst were involved in associating multiple cues associated with goals, while right HF was not necessary for this type of learning. These results suggest a revised role for avian HF. HF, particularly right HF, serves an important role in memory for the contents of goal locations. Furthermore, the current results are suggestive of a role for avian HF in episodic-like memory, which includes memory for both the spatial and temporal context of events.
Advisors/Committee Members: Bingman, Verner.
Subjects: Psychobiology; Psychology
Keywords: avian; hippocampus; spatial learning; learning and memory
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25.
Kahn, Patricia Hymson.
HOW THE SOCIAL REFORM MOVEMENT IMPACTED HANDIWORK AT HINDMAN SETTLEMENT SCHOOL IN HINDMAN, KENTUCKY DURING 1902-1920.
Degree: Doctor of Philosophy, Art Education, 2003, Ohio State University
► The purpose of this narrative, qualitative, socio-cultural historical study is to examine…
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▼ The purpose of this narrative, qualitative, socio-cultural historical study is to examine and understand how larger national and state systems of social reform affected the handiwork in the local region of Hindman, Kentucky, located in the eastern Kentucky Appalachian Mountains. This study offers a different look at the traditional handiwork, of Hindman Settlement School, through ethnic influences, environment, reform, and cottage craft industry in the region during the years 1902-1920. Historical themes emerged from the data: correcting the harm of the Industrial Revolution and progress through handiwork, creating handicrafts with a holistic process versus a specific factory line tasks, manual labor taught with an academic curriculum versus only vocational training for the factory, isolation from neighbors and community versus involvement, and progressive educational theories including notions of John Dewey and Jane Addams, that related ot the local setting. A strong connection is made with the Neighborhood House located in Louisville, Kentucky to Hindman Settlement School. The school still in operration today, was respected for its academics, handiwork, and response to the region's educational needs.
Advisors/Committee Members: Efland, Arthur.
Subjects: Education, Art
Keywords: Social Reform Movement; Social Settlement Movement; Appalachian Crafts; Hindman Settlement School; Jane Addams; John Dewey; Katherine Pettit; May Stone
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26.
Kahrig, Tammy.
An Evaluation of the Residential Learning Communities Program at Ohio University: An Analysis of Student Involvement, Satisfaction, Academic Success, and Retention.
Degree: Doctor of Philosophy (PhD), Higher Education (Education), 2005, Ohio University
► As a result of the many dramatic forces shaping the climate for…
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▼ As a result of the many dramatic forces shaping the climate for higher education, a number of new initiatives for improving the undergraduate experience have emerged on college and university campuses across the United States. The Residential Learning Communities program at Ohio University, built on the learning community model of freshman interest groups with the addition of a residential component, was launched in fall 2000 with five goals in mind: a) create residential, learning-based peer networks, b) improve academic success of first-year students, c) improve student retention from the freshman to sophomore year, d) increase student satisfaction with the university, and e) increase student-faculty interaction outside the classroom. The purpose of this study was to determine the effectiveness of the Residential Learning Communities program in achieving, in its first full year of operation, its goals of enhancing the first-year experience at Ohio University. Utilizing available data from the university’s Student Involvement Questionnaire and student information system, this study sought to identify whether there were differences in involvement with peers, academic involvement, involvement with faculty, student satisfaction, academic success, and retention based on participation in learning community participation, major declaration status, and gender, controlling for preadmission characteristics. Analysis of Covariance tests or chi-square tests of independence were used to test the null hypotheses. Results were inconclusive for many of the dependent variables under study, but significant interaction effects were found for hours of involvement with peers, academic involvement, and student satisfaction.
Advisors/Committee Members: Moden, Gary.
Subjects: Education, Higher
Keywords: Learning Communities; Student Involvement; First Year Experience; Academic Success; Retention; Resdence Life
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27.
Kai, Junhai.
Protein Lab-on-a-Chips on Polyer Substrates for Point-of-Care Testing (POCT) of Cardiac Biomarkers.
Degree: PhD, Engineering : Electrical Engineering, 2006, University of Cincinnati
► Cardiac disease is the major cause of death in patients with end-stage…
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▼ Cardiac disease is the major cause of death in patients with end-stage renal disease, accounting for about 40% of all deaths. Cardiovascular diseases account for a significant number of mortalities in the United States especially in the 50 – 65 age range. The fast growing numbers of such patients generate great demand for a commercially available lab-on-a-chip which is able to carry out not only fast, reliable, and accurate measurements but also in portable or disposable format at low cost. In this research, a disposable protein lab-on-a-chip on a Cyclic-Olefin Copolymer (COC) is designed, fabricated and calibrated for monitoring human cardiac biomarkers. The multi-analyte protein lab-on-a-chip is able to perform rapid and accurate measurement of multiple cardiac biomarkers in human serum, such as CRP, Myoglobin, c-Tnl and BNP. By integration into a portable analyzer system, point-of-care testing (POCT) of cardiac biomarker measurement can be realized. Comparing with commercially available cardiac biomarker diagnostic systems, this work mainly focuses on an inexpensive platform for disposable biochip applied for multi-analyte point-of-care testing. Many novel methods and technologies are then developed and extensively tested such as low-cost polymer fabrication process and self-spotting antibody patterning. The proposed protein lab-on-a-chip will be able to measure multiple types of cardiac biomarkers in human serum, such as CRP, Myoglobin, c-Tnl and BNP. In the proposed protein lab-on-a-chip, fluorescence and chemiluminescence based solid phase immunoassay techniques will be applied for sensing. In this work, multiple parameters that can affect cardiac biomarker immunoassay performances in protein lab-on-a-chip are extensively studied and used for computer-based simulation. The protein lab-on-a-chip configuration is then characterized and optimized based on the simulation and experimental results. By integration into a portable optical detection system and an automatic microfluidic control system, point-of-care testing of human cardiac biomarkers can be realized. In addition, by adopting different types of antibodies, the proposed protein lab-on-a-chip also can be easily extended to the detection of other biomarkers and proteins for clinical diagnostics.
Advisors/Committee Members: Ahn, Dr. Chong H.
Keywords: Lab-on-a-chip; Cardiac biomarker; multi-analyte; Protein chip; Chemiluminescence; immunoassay; BioMEMS; Polymer microfabrication
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28.
KAIMAL, VINOD.
In VivoMR Microscopy of Tumor Targeted Liposome Combining USPIO and Saposin-C.
Degree: PhD, Engineering : Biomedical Engineering, 2007, University of Cincinnati
► In recent years, molecular imaging, defined as the visualization of biologic process…
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▼ In recent years, molecular imaging, defined as the visualization of biologic process in vivoat the molecular level, has gained prominence in the detection and monitoring of cancerous tissue. Several targets for the molecular imaging of cancer have been identified but in order to produce selective contrast enhancement, target specific contrast agent delivery methods and optimized imaging techniques need to be developed. This dissertation describes a molecular imaging approach that uses liposomes loaded with Ultra-small Super-Paramagnetic Iron Oxide (USPIO) nanoparticles targeted to tumor cells. Liposomes made from dioleylphosphatidylserine, (DOPS) are being used as carriers for Saposin-C, a fusogenic protein, currently being investigated for its effect in inducing cell death in a variety of human cancer cells. We developed an efficient method for loading Saposin-C-DOPS liposomes with USPIO. Further, we tested the uptake and MR detectability of these contrast-laden liposomes, referred to as ScDOPS-IO, in vitroin tumor cell cultures. Finally, we evaluated the feasibility of detecting ScDOPS-IO liposomes using MR imaging in vivo. The ScDOPS-IO liposomes encapsulated an average of 94.8±12.8 µg Fe /ml when a 1:30 molar ratio of saposin-C to DOPS was used with 1 mM DOPS and exhibited a transverse relaxivity (r2) of 101.21±4.9 mM-1s-1. Uptake in tumor cell cultures was found to be proportional to both time of exposure and initial concentration of ScDOPS-IO in growth medium. The cells were MR detectable against a uniform agarose background when average encapsulation was greater that 1 pg Fe/cell, using high resolution T2* weighted MR imaging. In vivoexperiments indicate accumulation of ScDOPS-IO in tumor xenografts in mice and T2 mapping of the xenografts show a significant drop in mean tumor T2 about 4 hours post injection of ScDOPS-IO. These results demonstrate the feasibility of using MR imaging for quantitative estimation of delivery and uptake of targeted drugs and early detection of tumors using targeted contrast agents. The methods presented here are promising for translation to applications in human subjects for clinical trials of new chemotherapy drugs.
Advisors/Committee Members: Holland, Scott K.
Subjects: Engineering, Biomedical
Keywords: USPIO; Saposin-C; liposome; magnetic resonance imaging; MRI
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29.
KAIMAL, VINOD GOPALKRISHNA.
A NEURAL METHOD OF COMPUTING OPTICAL FLOW BASED ON GEOMETRIC CONSTRAINTS.
Degree: MS, Engineering : Electrical Engineering, 2002, University of Cincinnati
► Determining optical flow is a fundamental problem in computer vision and image…
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▼ Determining optical flow is a fundamental problem in computer vision and image analysis. Optical flow is the projection of three dimensional motion of objects onto a plane, estimated from a sequence of two dimensional images. However, as this is an ill posed problem, i.e. has no unique solution based on available information thus requiring additional constraints to make the problem well posed. We propose an algorithm based on feature matching using Hopfield Networks to determine the optical flow field between a sequence of images. We formulate the correspondence between features extracted from the two images as an optimization problem using a new robust disparity measure. The Hopfield network is then used to minimize the cost function and obtain an optimal match between the features in successive frames. This thesis offers a review of relevant literature and a detailed description of the algorithm. We then evaluate the performance of the algorithm on a variety of test sequences, both artificial and real. The results are found to be comparable to those obtained by other feature based algorithms, which suggests the use of Hopfield type networks in practical vision algorithms.
Advisors/Committee Members: Minai, Dr. Ali.
Keywords: optical flow; computer vision; neural networks; Hopfield networks; image processing
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30.
Kain, Jason Matthew.
The Relationship between workplace incivility and strain: Equity sensitivity as a moderator.
Degree: Master of Arts (MA), Psychology/Industrial-Organizational, 2008, Bowling Green State University
► The current study tested the influence of equity sensitivity on the relationship…
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▼ The current study tested the influence of equity sensitivity on the relationship between experienced and perpetrated incivility and health outcomes (affective well-being and depression). More specifically, it was hypothesized that entitlement would moderate the relationship between both experienced and perpetrated incivility and affective well-being and depression. Due to measurement limitations with the Equity Sensitivity Instrument (ESI), a new measure, the Equity Sensitivity Questionnaire (ESQ) was developed and tested to use in this study. Data was collected from 225 university employees in 179 departments. Results indicated that people who are more highly entitled tend to experience more incivility. Additionally, people who experience more incivility tend to have lower levels of affective well-being. Results also showed that people who experience more incivility also tend to engage in perpetrated incivility more frequently. Moderator hypotheses were not supported using either the ESQ or ESI.
Advisors/Committee Members: Jex, Steve.
Subjects: Psychology
Keywords: incivility; equity sensitivity; affective well-being; depression
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